Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.67 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.56 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HSD3B1 | P14060 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9022270 | 0.92 | AR (0.68) | ARSRD5A2SRD5A1KCNH2ABCC4 | |
| SCHEMBL9022263 | 0.92 | AR (0.68) | ARSRD5A2SRD5A1KCNH2ABCC4 | |
| SCHEMBL9022545 | 0.92 | AR (0.68) | ARSRD5A2SRD5A1KCNH2ABCC4 | |
| SCHEMBL9022541 | 0.92 | AR (0.68) | ARSRD5A2SRD5A1KCNH2ABCC4 | |
| SCHEMBL8376192 | 0.89 | SRD5A2 (0.71) | ARSRD5A2SRD5A1KCNH2ABCC4 | |
| SCHEMBL8376189 | 0.89 | SRD5A2 (0.71) | ARSRD5A2SRD5A1KCNH2ABCC4 | |
| SCHEMBL8074137 | 0.88 | SRD5A2 (0.70) | ARSRD5A2SRD5A1KCNH2 | |
| SCHEMBL8074134 | 0.88 | SRD5A2 (0.70) | ARSRD5A2SRD5A1KCNH2 | |
| SCHEMBL17471494 | 0.88 | AR (0.67) | ARSRD5A2SRD5A1KCNH2ABCC4 | |
| SCHEMBL7790540 | 0.88 | AR (0.67) | ARSRD5A2SRD5A1KCNH2ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1420796-A4 | ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF | MERCK & CO INC (US) | 2007-07-11 | — | — | EP | claimed |
| EP-1420796-A1 | ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF | Merck & Co., Inc. (US) | 2004-05-26 | — | — | EP | claimed |
| WO-2003011302-A1 | ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF | MERCK & CO., INC. (US) | 2003-02-13 | — | — | WO | claimed |