Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.56 |
| ▸ | CNR2 | P34972 | 4/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5571545 | 0.90 | P2RX7 (0.52) | P2RX7CNR2CRHR1KAT6AKAT8 | |
| SCHEMBL4469580 | 0.89 | P2RX7 (0.51) | P2RX7CNR2CRHR1KAT6AKAT8 | |
| SCHEMBL4460902 | 0.88 | P2RX7 (0.50) | P2RX7CNR2CRHR1KAT6AKAT8 | |
| SCHEMBL2180488 | 0.88 | P2RX7 (0.50) | P2RX7CNR2CRHR1KAT6AKAT8 | |
| SCHEMBL4466795 | 0.87 | P2RX7 (0.51) | P2RX7CNR2CRHR1KAT6AKAT8 | |
| SCHEMBL13372727 | 0.87 | P2RX7 (0.47) | P2RX7CNR2CRHR1KAT6AKAT8 | |
| SCHEMBL4469159 | 0.86 | P2RX7 (0.49) | P2RX7CNR2CRHR1KAT6AKAT8 | |
| SCHEMBL4463057 | 0.85 | P2RX7 (0.47) | P2RX7CNR2CRHR1KAT6AKAT8 | |
| SCHEMBL4472724 | 0.85 | P2RX7 (0.47) | P2RX7CNR2CRHR1KAT6AKAT8 | |
| SCHEMBL2180874 | 0.85 | P2RX7 (0.57) | P2RX7CNR2CRHR1KAT6AKAT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626962-B1 | BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | PFIZER PROD INC (US) | 2007-02-28 | — | — | EP | claimed |
| EP-1837330-B1 | Benzamide inhibitors of the P2X7 receptor | PFIZER PROD INC (US) | 2012-10-24 | — | — | EP | disclosed |
| EP-1837330-A1 | Benzamide inhibitors of the P2X7 receptor | Pfizer Products Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| EP-1626962-B1 | BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | PFIZER PROD INC (US) | 2007-02-28 | — | — | EP | disclosed |