Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 5/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.55 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5216275 | 0.91 | HTR1F (0.79) | HTR1FKCNK3ACKR3 | |
| SCHEMBL5216477 | 0.89 | HTR1F (0.64) | HTR1FMAPTNPSR1NPC1RAB9A | |
| SCHEMBL5216542 | 0.88 | HTR1F (0.82) | HTR1FKCNK3KCNK9NPC1RAB9A | |
| SCHEMBL5211098 | 0.87 | HTR1F (0.61) | HTR1FNPSR1NPC1RAB9ALMNA | |
| SCHEMBL5208639 | 0.87 | HTR1F (0.73) | HTR1FKCNK3KCNK9BRAFNPC1 | |
| SCHEMBL5207850 | 0.87 | HTR1F (0.60) | HTR1FNPSR1BRAFLMNA | |
| SCHEMBL5213663 | 0.86 | HTR1F (0.80) | HTR1FACKR3 | |
| SCHEMBL5216706 | 0.86 | HTR1F (0.72) | HTR1FMAPTNPC1RAB9A | |
| SCHEMBL5213369 | 0.86 | HTR1F (0.83) | HTR1FKCNK3KCNK9NPC1RAB9A | |
| Oxalic Acid SCHEMBL5208197 | 0.86 | HTR1F (0.79) | HTR1FKCNK3KCNK9NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153013-B1 | 5-HT1F AGONISTS | LILLY CO ELI (US) | 2007-10-31 | — | — | EP | disclosed |
| US-6777428-B1 | INHIBIT PEPTIDE EXTRAVASATION DUE TO STIMULATION OF THE TRIGEMINAL GANGLIA, AND ARE THEREFORE USEFUL FOR THE TREATMENT OF MIGRAINE AND ASSOCIATED DISORDERS | ELI LILLY AND COMPANY | 2004-08-17 | — | — | US | disclosed |
| CN-1149195-C | 5-HTIF agonists | — | 2004-05-12 | — | — | CN | disclosed |
| EP-1153013-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2001-11-14 | — | — | EP | disclosed |
| WO-2000047559-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2000-08-17 | — | — | WO | disclosed |