Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | LCAT | P04180 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5214840 | 0.99 | HRH3 (0.60) | HRH3CYP3A4DHFRSLC6A9NR1H2 | |
| SCHEMBL5211308 | 0.85 | HRH3 (0.44) | HRH3SLC6A9LCAT | |
| SCHEMBL5211979 | 0.81 | HRH3 (0.48) | HRH3SLC6A9 | |
| Hydrochloric Acid SCHEMBL5215054 | 0.81 | HRH3 (0.47) | HRH3SLC6A9 | |
| SCHEMBL5212095 | 0.81 | HRH3 (0.48) | HRH3CYP3A4DHFRLCATCHRM4 | |
| Hydrochloric Acid SCHEMBL5210871 | 0.80 | HRH3 (0.47) | HRH3CYP3A4DHFRLCATCHRM4 | |
| SCHEMBL3859666 | 0.79 | HRH3 (0.92) | HRH3CYP3A4SLC6A9CHRM4 | |
| SCHEMBL5209950 | 0.79 | HRH3 (0.48) | HRH3SLC6A9 | |
| Hydrochloric Acid SCHEMBL3878761 | 0.78 | HRH3 (0.90) | HRH3CYP3A4SLC6A9CHRM4 | |
| SCHEMBL5212466 | 0.78 | HRH3 (0.48) | HRH3LCAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646620-B1 | SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LTD (GB) | 2007-08-15 | — | — | EP | claimed |
| EP-1646620-B1 | SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LTD (GB) | 2007-08-15 | — | — | EP | disclosed |