Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.52 |
| ▸ | SLC5A7 | Q9GZV3 | 2/20 | 0.47 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.41 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5212064 | 0.99 | HRH3 (0.51) | HRH3SLC5A7CHRNA10CHRNA9LMNA | |
| SCHEMBL5212749 | 0.87 | HRH3 (0.54) | HRH3SLC5A7 | |
| Hydrochloric Acid SCHEMBL5212448 | 0.86 | HRH3 (0.53) | HRH3SLC5A7 | |
| SCHEMBL5208830 | 0.83 | HRH3 (0.53) | HRH3DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL5215566 | 0.82 | HRH3 (0.52) | HRH3DRD2DRD4 | |
| SCHEMBL5211181 | 0.82 | HRH3 (0.53) | HRH3 | |
| SCHEMBL5210189 | 0.78 | HRH3 (0.50) | HRH3 | |
| SCHEMBL5210912 | 0.78 | HRH3 (0.55) | HRH3 | |
| SCHEMBL5213401 | 0.75 | HRH3 (0.53) | HRH3 | |
| SCHEMBL5209970 | 0.75 | HRH3 (0.56) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646620-B1 | SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LTD (GB) | 2007-08-15 | — | — | EP | claimed |
| EP-1646620-A1 | SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005014571-A1 | SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2005-02-17 | — | — | WO | disclosed |