Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 16/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5213329 | 0.89 | CNR2 (0.62) | CNR2ABL1BCRCNR1CYP3A4 | |
| SCHEMBL5215525 | 0.88 | CNR2 (0.63) | CNR2CNR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5215693 | 0.86 | CNR2 (0.59) | CNR2CNR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5212172 | 0.86 | CNR2 (0.68) | CNR2CNR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4648950 | 0.79 | CNR2 (0.72) | CNR2MEN1KMT2A | |
| SCHEMBL5212777 | 0.79 | CNR2 (0.61) | CNR2 | |
| SCHEMBL5212774 | 0.79 | CNR2 (0.61) | CNR2 | |
| SCHEMBL5213596 | 0.79 | CNR2 (0.61) | CNR2 | |
| SCHEMBL14381004 | 0.77 | CNR2 (0.56) | CNR2CNR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3382290 | 0.76 | CNR2 (0.56) | CNR2CYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565442-B1 | PYRIDINE DERIVATIVES AS CB2 RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2007-11-14 | — | — | EP | claimed |
| EP-1565442-B1 | PYRIDINE DERIVATIVES AS CB2 RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2007-11-14 | — | — | EP | disclosed |