Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 6/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.43 |
| ▸ | CDK4 | P11802 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214613 | 0.91 | EIF2AK2 (0.46) | EIF2AK2GSK3BMAPK10CDK4CDK1 | |
| SCHEMBL5214999 | 0.91 | EIF2AK2 (0.46) | EIF2AK2GSK3BMAPK10CDK4KDR | |
| SCHEMBL5215526 | 0.90 | CSNK1D (0.47) | GSK3BMAPK10CDK4CDK2CSNK1D | |
| SCHEMBL5216777 | 0.90 | GSK3B (0.47) | EIF2AK2GSK3BMAPK10CDK4MKNK1 | |
| SCHEMBL5214934 | 0.84 | EIF2AK2 (0.51) | EIF2AK2GSK3BMAPK10CDK4 | |
| SCHEMBL5890307 | 0.83 | EIF2AK2 (0.50) | EIF2AK2GSK3BMAPK10CDK4 | |
| SCHEMBL5890132 | 0.82 | EIF2AK2 (0.49) | EIF2AK2GSK3BMAPK10 | |
| SCHEMBL6105305 | 0.82 | EIF2AK2 (0.51) | EIF2AK2GSK3BMAPK10CDK4KDR | |
| SCHEMBL5453019 | 0.82 | EIF2AK2 (0.50) | EIF2AK2GSK3BMAPK10CDK4KDR | |
| SCHEMBL5890058 | 0.81 | EIF2AK2 (0.49) | EIF2AK2GSK3BMAPK10CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423389-B1 | PYRAZOLO-PYRIDINES FOR THE TREATMENT OF HERPES INFECTIONS | SMITHKLINE BEECHAM CORP (US) | 2007-06-06 | — | — | EP | claimed |
| EP-1423389-B1 | PYRAZOLO-PYRIDINES FOR THE TREATMENT OF HERPES INFECTIONS | SMITHKLINE BEECHAM CORP (US) | 2007-06-06 | — | — | EP | disclosed |