Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 6/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5725747 | 0.93 | EIF2AK2 (0.48) | EIF2AK2GSK3BMAPK10MAPK8MAPK9 | |
| SCHEMBL5220849 | 0.90 | EIF2AK2 (0.50) | EIF2AK2GSK3BMAPK10MAPK8MAPK9 | |
| SCHEMBL5726088 | 0.89 | EIF2AK2 (0.42) | EIF2AK2GSK3BMAPK10MAPK8MAPK9 | |
| SCHEMBL5726203 | 0.89 | EIF2AK2 (0.41) | EIF2AK2GSK3BMAPK10MAPK8MAPK9 | |
| SCHEMBL5214451 | 0.88 | CSNK1D (0.51) | GSK3BMAPK10MAPK8MAPK9CDK4 | |
| SCHEMBL5725916 | 0.88 | MAPK8 (0.43) | GSK3BMAPK10MAPK8MAPK9CDK4 | |
| SCHEMBL5214737 | 0.84 | EIF2AK2 (0.47) | EIF2AK2GSK3BMAPK10CDK4 | |
| SCHEMBL5725659 | 0.82 | MAPK9 (0.46) | GSK3BMAPK10MAPK8MAPK9CDK4 | |
| SCHEMBL5724993 | 0.82 | CSNK1D (0.48) | GSK3BMAPK10MAPK8MAPK9CDK4 | |
| SCHEMBL6105305 | 0.82 | EIF2AK2 (0.51) | EIF2AK2GSK3BMAPK10CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377575-B1 | ANTIVIRAL PYRAZOLOPYRIDINE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2006-07-05 | — | — | EP | claimed |
| EP-1423389-B1 | PYRAZOLO-PYRIDINES FOR THE TREATMENT OF HERPES INFECTIONS | SMITHKLINE BEECHAM CORP (US) | 2007-06-06 | — | — | EP | disclosed |