Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 13/20 | 0.71 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | DRD5 | P21918 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1E | P28566 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212590 | 0.92 | HTR1F (0.76) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL5212444 | 0.90 | HTR1F (0.76) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL5215502 | 0.88 | HTR1F (0.70) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL5211907 | 0.88 | HTR1F (0.76) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL5212700 | 0.87 | HTR1F (0.71) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL5215346 | 0.87 | HTR1F (0.78) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL5213663 | 0.86 | HTR1F (0.80) | HTR1FKMT2AMEN1CCNA2CDK2 | |
| SCHEMBL5213369 | 0.85 | HTR1F (0.83) | HTR1FKMT2AMEN1SMN1; SMN2CYP2C9 | |
| SCHEMBL5209973 | 0.85 | HTR1F (0.83) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL5213316 | 0.84 | HTR1F (0.77) | HTR1FCHRM5DRD5HTR1DHTR1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153013-B1 | 5-HT1F AGONISTS | LILLY CO ELI (US) | 2007-10-31 | — | — | EP | disclosed |
| US-6777428-B1 | INHIBIT PEPTIDE EXTRAVASATION DUE TO STIMULATION OF THE TRIGEMINAL GANGLIA, AND ARE THEREFORE USEFUL FOR THE TREATMENT OF MIGRAINE AND ASSOCIATED DISORDERS | ELI LILLY AND COMPANY | 2004-08-17 | — | — | US | disclosed |