Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 14/20 | 0.60 |
| ▸ | ULK1 | O75385 | 2/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.40 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.40 |
| ▸ | STK16 | O75716 | 2/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | BMP2K | Q9NSY1 | 2/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | ULK3 | Q6PHR2 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.39 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5213222 | 0.91 | PTK2 (0.48) | PTK2ULK1PTK2BCDK1CCNB1 | |
| SCHEMBL5210356 | 0.90 | PTK2 (0.60) | PTK2PTK2B | |
| SCHEMBL5213474 | 0.90 | PTK2 (0.61) | PTK2ULK1PTK2BCDK1CCNB1 | |
| SCHEMBL6209598 | 0.89 | PTK2 (0.44) | PTK2CDK1NTRK1NUAK1STK16 | |
| SCHEMBL6212141 | 0.88 | KDM4E (0.43) | PTK2PTK2BCDK1CCNB1NTRK1 | |
| SCHEMBL6212597 | 0.88 | NTRK1 (0.49) | PTK2NTRK1 | |
| SCHEMBL6242541 | 0.87 | KDM4E (0.50) | PTK2NTRK1JAK3 | |
| SCHEMBL6236688 | 0.87 | PTK2 (0.42) | PTK2PTK2BCDK1CCNB1NTRK1 | |
| SCHEMBL6211739 | 0.87 | PTK2 (0.51) | PTK2CDK1CCNB1CDK7NTRK1 | |
| SCHEMBL6210939 | 0.87 | HTR2C (0.42) | PTK2CDK1NTRK1NUAK1STK16 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758887-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Incorporated (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005111016-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2005-11-24 | — | — | WO | claimed |
| US-20050256111-A1 | Pyrimidine derivatives for the treatment of abnormal cell growth | PFIZER INC | 2005-11-17 | — | — | US | claimed |
| US-7235562-B2 | Pyrimidine derivatives for the treatment of abnormal cell growth | PFIZER INC (US) | 2007-06-26 | — | — | US | disclosed |
| EP-1758887-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Incorporated (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005111016-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2005-11-24 | — | — | WO | disclosed |
| US-20050256111-A1 | Pyrimidine derivatives for the treatment of abnormal cell growth | PFIZER INC | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256111-A1 | Pyrimidine derivatives for the treatment of abnormal cell growth | TYMS, TYMP, CCNA1 | PTK2 3610/4885ULK1 3275/4885PTK2B 3168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.