Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 3/20 | 0.40 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236688 | 0.94 | PTK2 (0.42) | KDM4EALDH1A1MAPTHSD17B10HTR2C | |
| Trifluoroacetic Acid SCHEMBL6236987 | 0.93 | NTRK1 (0.41) | KDM4EALDH1A1MAPTHSD17B10HTR2C | |
| SCHEMBL6241707 | 0.93 | KDM4E (0.43) | KDM4EALDH1A1MAPTHSD17B10HTR2C | |
| SCHEMBL6236216 | 0.92 | STK17B (0.42) | KDM4EALDH1A1MAPTHSD17B10HTR2C | |
| SCHEMBL6237654 | 0.92 | KDM4E (0.42) | KDM4EALDH1A1MAPTHSD17B10HTR2C | |
| SCHEMBL6239654 | 0.92 | CDK1 (0.44) | KDM4EALDH1A1MAPTHSD17B10HTR2C | |
| SCHEMBL6210939 | 0.92 | HTR2C (0.42) | KDM4EALDH1A1MAPTHSD17B10HTR2C | |
| SCHEMBL6212597 | 0.92 | NTRK1 (0.49) | CDK9PTK2NTRK1 | |
| SCHEMBL6209598 | 0.92 | PTK2 (0.44) | KDM4EALDH1A1MAPTHSD17B10HTR2C | |
| SCHEMBL6243567 | 0.91 | TBK1 (0.43) | KDM4EALDH1A1MAPTHSD17B10HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578732-A2 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | claimed |
| WO-2004056786-A2 | PYRIMIDINE DERIVATES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | claimed |
| EP-1578732-A2 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056786-A2 | PYRIMIDINE DERIVATES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |