Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214826 | 0.90 | CCR2 (0.48) | CCR2SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL5214833 | 0.90 | CCR2 (0.48) | CCR2SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL5219974 | 0.87 | CCR2 (0.63) | CCR2LMNAMAPTHTTALDH1A1 | |
| SCHEMBL5219665 | 0.86 | CCR2 (0.56) | CCR2SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL5216150 | 0.83 | CCR2 (0.55) | CCR2SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL5215724 | 0.81 | CCR2 (0.50) | CCR2SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL5213680 | 0.80 | CCR2 (0.65) | CCR2SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL5216641 | 0.79 | MEN1 (0.63) | CCR2SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL5214927 | 0.79 | CCR2 (0.59) | CCR2SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL5216535 | 0.79 | CCR2 (0.59) | CCR2SMN1; SMN2LMNAMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173421-B1 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | ASTRAZENECA AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| US-6833387-B1 | 3-substituted indoles; inhibition of monocyte chemoattractant protein-1 and/or RANTES induced chemotaxis; inflammatory diseases | ASTRAZENECA AB (SE) | 2004-12-21 | — | — | US | disclosed |