SCHEMBL5216499

SCHEMBL5216499

c1cc(-c2ccc(C34CCCN(CC3)C4)cn2)ccn1

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 1/20 0.38
HCRTR1 O43613 1/20 0.35
HCRTR2 O43614 1/20 0.35
CYP11B1 P15538 1/20 0.35
CYP11B2 P19099 1/20 0.35
ROCK2 O75116 6/20 0.34
ROCK1 Q13464 6/20 0.34
HDAC1 Q13547 1/20 0.32
HDAC2 Q92769 1/20 0.32
CHEK1 O14757 1/20 0.32
GSK3B P49841 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL4477940 0.99 ALOX5AP (0.37) ALOX5APHCRTR1HCRTR2CYP11B1CYP11B2
SCHEMBL2679668 0.97 ALOX5AP (0.39) ALOX5APHCRTR1HCRTR2CYP11B1CYP11B2
SCHEMBL2678500 0.94 ALOX5AP (0.38) ALOX5APCYP11B1CYP11B2ROCK2ROCK1
SCHEMBL4463296 0.88 HSD11B1 (0.40) HCRTR1HCRTR2
Bromide SCHEMBL4471147 0.86 HSD11B1 (0.39) HCRTR1HCRTR2
SCHEMBL5221717 0.86 CYP2A6 (0.47) ALOX5APHCRTR1HCRTR2CYP11B1CYP11B2
Bromide SCHEMBL4468359 0.85 CYP2A6 (0.46) ALOX5APHCRTR1HCRTR2CYP11B1CYP11B2
SCHEMBL2678244 0.85 HSD11B1 (0.41) CYP11B1CYP11B2
Bromide SCHEMBL4461513 0.84 CHRNA7 (0.39) ALOX5APROCK1
SCHEMBL2679498 0.83 ALOX5AP (0.41) ALOX5APCYP11B1ROCK2ROCK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1465893-B1 DERIVATIVES OF 5-(PYRIDIN-3-YL)-1-AZABICYCLO (3.2.1) OCTANE, THE PREPARATION THEREOF AND THE APPLICATION OF SAME IN THERAPEUTICS SANOFI AVENTIS (FR) 2007-02-28 EP claimed