Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 8/20 | 0.49 |
| ▸ | BCHE | P06276 | 7/20 | 0.49 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13073581 | 0.87 | BCHE (0.48) | BACE1BCHECSNK1EF2LMNA | |
| SCHEMBL3455222 | 0.86 | BACE1 (0.62) | BACE1BCHE | |
| SCHEMBL161260 | 0.86 | BACE1 (0.62) | BACE1BCHE | |
| SCHEMBL8276492 | 0.86 | BACE1 (0.62) | BACE1BCHE | |
| Hydrochloric Acid SCHEMBL2499284 | 0.85 | BACE1 (0.61) | BACE1BCHE | |
| SCHEMBL257187 | 0.85 | BACE1 (0.49) | BACE1BCHE | |
| SCHEMBL4043821 | 0.84 | BACE1 (0.48) | BACE1BCHECSNK1EF2LMNA | |
| SCHEMBL4691037 | 0.84 | BACE1 (0.56) | BACE1BCHECSNK1EF2 | |
| SCHEMBL3353939 | 0.83 | BCHE (0.61) | BACE1BCHECSNK1EF2LMNA | |
| SCHEMBL496172 | 0.83 | BCHE (0.61) | BACE1BCHECSNK1EF2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |