Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 4/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5216749 | 1.00 | PPARG (0.40) | PPARGLTB4RTHRBTHRAHDAC8 | |
| SCHEMBL5674030 | 0.94 | KDM4E (0.39) | PPARGHDAC8S1PR1S1PR5 | |
| SCHEMBL5674028 | 0.94 | KDM4E (0.39) | PPARGHDAC8S1PR1S1PR5 | |
| SCHEMBL5673028 | 0.93 | PPARG (0.39) | PPARGLTB4RTHRBTHRAHDAC8 | |
| SCHEMBL5673021 | 0.93 | PPARG (0.39) | PPARGLTB4RTHRBTHRAHDAC8 | |
| SCHEMBL5673070 | 0.92 | HDAC8 (0.39) | PPARGLTB4RTHRBTHRAHDAC8 | |
| SCHEMBL5673081 | 0.92 | HDAC8 (0.39) | PPARGLTB4RTHRBTHRAHDAC8 | |
| SCHEMBL5672896 | 0.90 | LTB4R (0.39) | LTB4RTHRBTHRAHDAC8HTR2A | |
| SCHEMBL5672891 | 0.90 | LTB4R (0.39) | LTB4RTHRBTHRAHDAC8HTR2A | |
| SCHEMBL5214619 | 0.87 | PPARG (0.39) | PPARGTHRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142879-B1 | IMIDAZOLE COMPOUNDS AND MEDICINAL USE THEREOF | ASTELLAS PHARMA INC (JP) | 2007-10-10 | — | — | EP | disclosed |
| US-7060721-B1 | Imidazole compounds and medicinal use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2006-06-13 | — | — | US | disclosed |
| EP-1142879-A1 | IMIDAZOLE COMPOUNDS AND MEDICINAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |