Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.52 |
| ▸ | CTSD | P07339 | 2/20 | 0.52 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.52 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | CCR1 | P32246 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5217284 | 1.00 | BACE1 (0.52) | BACE1CTSDBACE2SLC6A11BCHE | |
| SCHEMBL5930046 | 0.92 | BACE1 (0.53) | BACE1CTSDBACE2SLC6A11BCHE | |
| SCHEMBL5930039 | 0.92 | BACE1 (0.53) | BACE1CTSDBACE2SLC6A11BCHE | |
| SCHEMBL5400909 | 0.86 | KLK5 (0.52) | BACE1CTSDBACE2BCHE | |
| SCHEMBL5400906 | 0.86 | KLK5 (0.52) | BACE1CTSDBACE2BCHE | |
| SCHEMBL5431141 | 0.84 | KDM4E (0.50) | BACE1SLC6A11 | |
| SCHEMBL5431147 | 0.84 | KDM4E (0.50) | BACE1SLC6A11 | |
| SCHEMBL7306846 | 0.83 | BACE1 (0.60) | BACE1SLC6A11BCHE | |
| SCHEMBL7305633 | 0.83 | BACE1 (0.60) | BACE1SLC6A11BCHE | |
| SCHEMBL5221965 | 0.81 | TACR2 (0.43) | BACE1CTSDBACE2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |