Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 14/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 12/20 | 0.43 |
| ▸ | CTSD | P07339 | 11/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219981 | 0.88 | BACE1 (0.40) | BACE1BACE2CTSDPOLBKDM4E | |
| SCHEMBL5217940 | 0.88 | POLB (0.57) | BACE1BACE2CTSDPOLB | |
| SCHEMBL5220223 | 0.79 | KMT2A (0.45) | POLBKDM4EMEN1ALDH1A1GAA | |
| SCHEMBL5219973 | 0.76 | POLB (0.46) | BACE1BACE2CTSDPOLB | |
| SCHEMBL5221877 | 0.76 | BACE1 (0.66) | BACE1BACE2CTSD | |
| SCHEMBL5221872 | 0.76 | BACE1 (0.66) | BACE1BACE2CTSD | |
| SCHEMBL6823081 | 0.75 | BACE1 (0.43) | BACE1BACE2CTSDPOLBKDM4E | |
| SCHEMBL5221190 | 0.75 | CTSD (0.34) | BACE1BACE2CTSDPOLBKDM4E | |
| SCHEMBL5218631 | 0.74 | POLB (0.44) | BACE1BACE2CTSDPOLBKDM4E | |
| SCHEMBL5222301 | 0.73 | POLB (0.43) | BACE1BACE2POLBKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |