Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCPS | Q96C86 | 12/20 | 0.57 |
| ▸ | DHFR | P00374 | 10/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1153969 | 0.82 | DCPS (0.78) | DCPSDHFRKCNH2 | |
| SCHEMBL15295903 | 0.80 | KCNH2 (0.67) | DCPSDHFRKCNH2 | |
| SCHEMBL1154309 | 0.80 | DCPS (0.62) | DCPSDHFRKCNH2 | |
| SCHEMBL1154426 | 0.79 | DCPS (0.61) | DCPSDHFRKCNH2 | |
| SCHEMBL1155037 | 0.75 | DCPS (0.62) | DCPSDHFRKCNH2 | |
| SCHEMBL1154656 | 0.73 | DCPS (0.83) | DCPSDHFRKCNH2 | |
| SCHEMBL30912749 | 0.73 | KCNH2 (1.00) | DCPSDHFRKCNH2 | |
| SCHEMBL29368711 | 0.73 | KCNH2 (1.00) | DCPSDHFRKCNH2 | |
| SCHEMBL8294968 | 0.73 | DCPS (0.69) | DCPSDHFRKCNH2 | |
| SCHEMBL15283857 | 0.73 | KCNH2 (1.00) | DCPSDHFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765810-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | Decode Chemistry, Inc. (US) | 2007-03-28 | — | — | EP | claimed |
| WO-2005123724-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | DECODE CHEMISTRY, INC. (US) | 2005-12-29 | — | — | WO | claimed |
| WO-2012167086-A2 | METHODS OF DIAGNOSING AND TREATING AMYOTROPHIC LATERAL SCLEROSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-12-06 | — | — | WO | disclosed |
| EP-1765810-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | Decode Chemistry, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123724-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | DECODE CHEMISTRY, INC. (US) | 2005-12-29 | — | — | WO | disclosed |