Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 19/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218232 | 0.82 | CCR5 (0.53) | CCR5KCNH2CYP2D6KCNJ1 | |
| SCHEMBL5219971 | 0.80 | CCR5 (0.60) | CCR5KCNH2CYP2D6 | |
| SCHEMBL5222946 | 0.80 | CCR5 (0.54) | CCR5KCNH2CYP2D6KCNJ1 | |
| SCHEMBL5220283 | 0.78 | CCR5 (0.61) | CCR5KCNH2CYP2D6 | |
| SCHEMBL3303563 | 0.78 | CCR5 (0.59) | CCR5KCNH2CYP2D6 | |
| Hydrochloric Acid SCHEMBL5222702 | 0.78 | CCR5 (0.61) | CCR5KCNH2CYP2D6 | |
| SCHEMBL5238997 | 0.77 | CCR5 (0.58) | CCR5KCNH2CYP2D6 | |
| SCHEMBL5235987 | 0.77 | CCR5 (0.61) | CCR5KCNH2CYP2D6 | |
| SCHEMBL5220551 | 0.76 | CCR5 (0.61) | CCR5KCNH2CYP2D6 | |
| SCHEMBL5434212 | 0.74 | CCR5 (0.62) | CCR5KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654229-B1 | PIPERIDINE DERIVATIVES AS CCR5 RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-05-09 | — | — | EP | disclosed |