Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 4/20 | 0.49 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.49 |
| ▸ | CTSD | P07339 | 3/20 | 0.49 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8275567 | 0.96 | MAPT (0.59) | POLBMAPTBACE1BACE2CTSD | |
| SCHEMBL5225441 | 0.88 | MAPT (0.56) | POLBMAPTBACE1BACE2CTSD | |
| SCHEMBL5218631 | 0.88 | POLB (0.44) | POLBMAPTBACE1BACE2CTSD | |
| SCHEMBL5396171 | 0.84 | MAPT (0.60) | POLBMAPTBACE1BACE2CTSD | |
| SCHEMBL5220214 | 0.83 | POLB (0.60) | POLBMAPTBACE1BACE2PTGER1 | |
| SCHEMBL3886939 | 0.79 | POLB (0.64) | POLBBACE1BACE2PTGER1TP53 | |
| SCHEMBL6823082 | 0.79 | POLB (0.57) | POLBBACE1BACE2CTSDPTGER1 | |
| SCHEMBL13229564 | 0.79 | POLB (0.60) | POLBMAPTBACE1BACE2PTGER1 | |
| SCHEMBL18767230 | 0.77 | POLB (0.55) | POLBMAPTBACE1BACE2CTSD | |
| SCHEMBL6206259 | 0.77 | POLB (0.49) | POLBMAPTBACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |