Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 8/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 5/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.38 |
| ▸ | CTSD | P07339 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823082 | 0.81 | POLB (0.57) | POLBTP53PTGER1BACE1BACE2 | |
| SCHEMBL8275567 | 0.81 | MAPT (0.59) | POLBMAPTTP53PTGER1SMN1; SMN2 | |
| SCHEMBL5218622 | 0.77 | POLB (0.60) | POLBMAPTTP53PTGER1BACE1 | |
| SCHEMBL18767065 | 0.76 | POLB (0.54) | POLBMAPTTP53PTGER1SMN1; SMN2 | |
| SCHEMBL5900600 | 0.75 | POLB (0.59) | POLBMAPTTP53PTGER1SMN1; SMN2 | |
| SCHEMBL6826724 | 0.75 | CTSD (0.50) | POLBMAPTTP53PTGER1SMN1; SMN2 | |
| SCHEMBL3886939 | 0.73 | POLB (0.64) | POLBTP53PTGER1BACE1BACE2 | |
| SCHEMBL13229564 | 0.73 | POLB (0.60) | POLBMAPTTP53PTGER1SMN1; SMN2 | |
| SCHEMBL5435268 | 0.72 | TP53 (0.47) | POLBMAPTTP53PTGER1SMN1; SMN2 | |
| SCHEMBL18767230 | 0.71 | POLB (0.55) | POLBMAPTTP53PTGER1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050619-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2004-06-17 | — | — | WO | disclosed |