Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.54 |
| ▸ | BCHE | P06276 | 5/20 | 0.53 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218800 | 1.00 | BACE1 (0.54) | BACE1BCHESLC6A11CTSD | |
| SCHEMBL5388473 | 0.87 | KLK5 (0.58) | BACE1BCHE | |
| SCHEMBL5388477 | 0.87 | KLK5 (0.58) | BACE1BCHE | |
| SCHEMBL5930161 | 0.87 | BACE1 (0.58) | BACE1BCHESLC6A11 | |
| SCHEMBL5930154 | 0.87 | BACE1 (0.58) | BACE1BCHESLC6A11 | |
| SCHEMBL7611434 | 0.82 | BCHE (0.59) | BACE1BCHESLC6A11 | |
| SCHEMBL7611427 | 0.82 | BCHE (0.59) | BACE1BCHESLC6A11 | |
| SCHEMBL7305608 | 0.79 | BCHE (0.56) | BACE1BCHESLC6A11 | |
| SCHEMBL7306846 | 0.79 | BACE1 (0.60) | BACE1BCHESLC6A11 | |
| SCHEMBL7305633 | 0.79 | BACE1 (0.60) | BACE1BCHESLC6A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |