Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SORD | Q00796 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27643759 | 0.85 | CKS1B (0.52) | GBA1USP2HPGDSMN1; SMN2TSHR | |
| SCHEMBL784807 | 0.84 | HRH4 (0.62) | GBA1HRH4 | |
| SCHEMBL5218581 | 0.81 | USP2 (0.51) | USP2HPGDSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL5218625 | 0.80 | USP2 (0.50) | USP2HPGDSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL3281735 | 0.76 | HPGD (0.47) | USP2HPGDSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL26289473 | 0.76 | CRHBP (0.57) | GBA1USP2HPGDSMN1; SMN2TSHR | |
| SCHEMBL5222137 | 0.74 | CKS1B (0.52) | HRH4CKS1BSKP1SKP2 | |
| SCHEMBL25379567 | 0.73 | GBA1 (0.52) | GBA1SMN1; SMN2HRH4SORD | |
| SCHEMBL30306132 | 0.73 | GBA1 (0.52) | GBA1SMN1; SMN2HRH4SORD | |
| SCHEMBL27902623 | 0.73 | CKS1B (0.51) | USP2HPGDSMN1; SMN2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664025-B1 | PYRROL DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | ASTRAZENECA AB (SE) | 2007-09-19 | — | — | EP | disclosed |