SCHEMBL5219604

SCHEMBL5219604

COC(=O)c1ccc(NC(=O)c2cc(OCCc3ccsc3)c3cc(C)oc3c2)nc1

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 20/20 0.52
KCNH2 Q12809 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13343240 0.93 GCK (0.61) GCKKCNH2
SCHEMBL2654561 0.87 TSHR (0.38) GCKKCNH2
SCHEMBL2655556 0.81 GCK (0.52) GCKKCNH2
SCHEMBL2654309 0.79 GCK (0.48) GCKKCNH2
SCHEMBL5221067 0.78 GCK (0.51) GCKKCNH2
SCHEMBL10253149 0.77 GCK (0.75) GCKKCNH2
SCHEMBL643910 0.74 GCK (0.77) GCKKCNH2
SCHEMBL2653534 0.73 GCK (0.58) GCKKCNH2
SCHEMBL2663626 0.73 GCK (0.59) GCKKCNH2
SCHEMBL2667940 0.72 GCK (0.68) GCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1578745-B1 BENZOFURAN DERIVATivES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREOF ASTRAZENECA AB (SE) 2007-11-14 EP disclosed