Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 16/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654604 | 0.92 | GCK (0.51) | GCKKCNH2NOX1ALDH1A1MAPK1 | |
| SCHEMBL5221627 | 0.89 | NOX1 (0.45) | GCKKCNH2NOX1ALDH1A1MAPK1 | |
| SCHEMBL5222914 | 0.86 | NOX1 (0.42) | GCKKCNH2NOX1HTTSMN1; SMN2 | |
| SCHEMBL2655556 | 0.84 | GCK (0.52) | GCKKCNH2 | |
| SCHEMBL2654597 | 0.81 | GCK (0.44) | GCKNOX1ALDH1A1MAPK1HTT | |
| SCHEMBL10253149 | 0.80 | GCK (0.75) | GCKKCNH2 | |
| SCHEMBL2666934 | 0.79 | NOX1 (0.44) | GCKKCNH2NOX1ALDH1A1MAPK1 | |
| SCHEMBL5219604 | 0.78 | GCK (0.52) | GCKKCNH2 | |
| SCHEMBL5218574 | 0.78 | PTGER1 (0.44) | GCKKCNH2NOX1HTTSMN1; SMN2 | |
| SCHEMBL2650573 | 0.77 | GCK (0.54) | GCKALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578745-B1 | BENZOFURAN DERIVATivES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREOF | ASTRAZENECA AB (SE) | 2007-11-14 | — | — | EP | disclosed |