Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.61 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.61 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NT5E | P21589 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219694 | 1.00 | ALDH1A1 (0.67) | ALDH1A1HTTAKR1C3AKR1C1AKR1C2 | |
| SCHEMBL14565694 | 1.00 | ALDH1A1 (0.67) | ALDH1A1HTTAKR1C3AKR1C1AKR1C2 | |
| SCHEMBL10950320 | 0.88 | ALDH1A1 (0.83) | ALDH1A1HTTAKR1C3AKR1C1AKR1C2 | |
| SCHEMBL10950323 | 0.88 | ALDH1A1 (0.83) | ALDH1A1HTTAKR1C3AKR1C1AKR1C2 | |
| SCHEMBL20184151 | 0.84 | AKR1C1 (0.75) | ALDH1A1HTTAKR1C3AKR1C1AKR1C2 | |
| SCHEMBL7814861 | 0.84 | AKR1C1 (0.75) | ALDH1A1HTTAKR1C3AKR1C1AKR1C2 | |
| SCHEMBL6934616 | 0.83 | ALDH1A1 (0.67) | ALDH1A1HTTAKR1C3AKR1C1AKR1C2 | |
| SCHEMBL6934618 | 0.83 | ALDH1A1 (0.67) | ALDH1A1HTTAKR1C3AKR1C1AKR1C2 | |
| SCHEMBL14565691 | 0.81 | SMN1; SMN2 (0.49) | ALDH1A1HTTAKR1C3AKR1C1AKR1C2 | |
| SCHEMBL5216896 | 0.81 | SMN1; SMN2 (0.49) | ALDH1A1HTTAKR1C3AKR1C1AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542680-B1 | 1, 4, 5-SUBSTITUTED 1, 2-DIHYDRO-PYRAZOL-3-ONE AND 3-ALKOXY-1H-PYRAZOLE DERIVATIVES AS TNF-ALPHA AND INTERLEUKIN LOWERING AGENTS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC (US) | 2007-03-07 | — | — | EP | disclosed |
| US-6967254-B2 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2005-11-22 | — | — | US | disclosed |
| EP-1542680-A1 | 1, 4, 5-SUBSTITUTED 1, 2-DIHYDRO-PYRAZOL-3-ONE AND 3-ALKOXY-1H-PYRAZOLE DERIVATIVES S TNF-ALPHA AND INTERLEUKIN LOWERING AGENTS FOR THE TREATMENT OF INFLAMMATIONS | Amgen Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| US-20040058918-A1 | Substituted heterocyclic compounds and methods of use | AMGEN, INC. | 2004-03-25 | — | — | US | disclosed |
| WO-2004022055-A1 | 1, 4, 5-SUBSTITUTED 1, 2-DIHYDRO-PYRAZOL-3-ONE AND 3-ALKOXY-1H-PYRAZOLE DERIVATIVES S TNF-ALPHA AND INTERLEUKIN LOWERING AGENTS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2004-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058918-A1 | Substituted heterocyclic compounds and methods of use | MYLK2, MAPT, HMGB1 | ALDH1A1 2222/4885HTT 989/4885AKR1C3 1381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.