Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4479130 | 0.99 | CYP11B1 (0.35) | CYP11B1CYP11B2CYP1A2ALOX15ALDH1A1 | |
| SCHEMBL4463819 | 0.84 | HSD11B1 (0.38) | CYP11B1CYP11B2CHRNA7 | |
| Bromide SCHEMBL4466117 | 0.83 | HSD11B1 (0.37) | CYP11B1CYP11B2CHRNA7 | |
| SCHEMBL4463770 | 0.83 | ALOX5AP (0.34) | CYP11B1CYP11B2ALOX5AP | |
| SCHEMBL4475112 | 0.82 | CHRNA7 (0.37) | CHRNA7ALOX5AP | |
| SCHEMBL4470449 | 0.82 | SLC6A2 (0.38) | ALDH1A1FYNCYP2D6CYP3A4 | |
| SCHEMBL4461401 | 0.81 | ALOX5AP (0.31) | ALOX5AP | |
| SCHEMBL2678588 | 0.81 | CYP11B1 (0.40) | CYP11B1CYP11B2CYP1A2ALOX15ALDH1A1 | |
| SCHEMBL1482889 | 0.80 | ALOX5AP (0.38) | CYP11B1CYP11B2FYNALOX5AP | |
| SCHEMBL4483243 | 0.80 | CYP2A6 (0.41) | CYP11B1CYP11B2CYP1A2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465893-B1 | DERIVATIVES OF 5-(PYRIDIN-3-YL)-1-AZABICYCLO (3.2.1) OCTANE, THE PREPARATION THEREOF AND THE APPLICATION OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2007-02-28 | — | — | EP | claimed |