Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5219918 | 0.98 | AKR1B1 (0.47) | AKR1B1KMT2ASMN1; SMN2ADRA2ACYP3A4 | |
| SCHEMBL3743731 | 0.76 | AKR1B1 (0.59) | AKR1B1KMT2ASMN1; SMN2ADRA2ACYP3A4 | |
| SCHEMBL14464764 | 0.74 | AKR1B1 (0.56) | AKR1B1KMT2ASMN1; SMN2ADRA2ACYP3A4 | |
| SCHEMBL837827 | 0.73 | AKR1B1 (0.50) | AKR1B1KMT2ASMN1; SMN2ADRA2ACYP3A4 | |
| SCHEMBL7637016 | 0.73 | AKR1B1 (0.55) | AKR1B1KMT2ASMN1; SMN2ADRA2ACYP3A4 | |
| SCHEMBL1021475 | 0.72 | AKR1B1 (0.54) | AKR1B1KMT2ASMN1; SMN2ADRA2ACYP3A4 | |
| Hydrochloric Acid SCHEMBL1182809 | 0.71 | ADRA2A (0.55) | AKR1B1KMT2ASMN1; SMN2ADRA2ACYP3A4 | |
| SCHEMBL23102301 | 0.70 | AKR1B1 (0.42) | AKR1B1KMT2ASMN1; SMN2ADRA2ACYP3A4 | |
| Hydrochloric Acid SCHEMBL29195762 | 0.70 | KMT2A (0.51) | KMT2ASMN1; SMN2MEN1LMNAMAPT | |
| SCHEMBL10308335 | 0.68 | AKR1B1 (0.41) | AKR1B1KMT2ASMN1; SMN2ADRA2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265138-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2007-09-04 | — | — | US | disclosed |
| US-7265138-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2007-09-04 | — | — | US | disclosed |
| EP-1818333-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| EP-1818333-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-08-15 | — | — | EP | disclosed |