Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 8/20 | 0.46 |
| ▸ | HRH1 | P35367 | 8/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7105701 | 0.87 | HRH2 (0.53) | KDM4EHRH2HRH1HRH3 | |
| SCHEMBL5216009 | 0.83 | HRH2 (0.54) | KDM4EHRH2HRH1HRH3 | |
| SCHEMBL5218206 | 0.83 | HRH2 (0.54) | KDM4EHRH2HRH1HRH3 | |
| SCHEMBL5217780 | 0.82 | KDM4E (0.59) | KDM4EHRH2HRH1HRH3 | |
| SCHEMBL5216362 | 0.78 | KDM4E (0.54) | KDM4EHRH2HRH1HRH3 | |
| SCHEMBL5216544 | 0.76 | KDM4E (0.51) | KDM4EHRH2HRH1HRH3 | |
| SCHEMBL7966211 | 0.75 | HRH2 (0.58) | KDM4EHRH2HRH1HRH3 | |
| SCHEMBL7979503 | 0.75 | HRH2 (0.58) | KDM4EHRH2HRH1HRH3 | |
| SCHEMBL5214617 | 0.74 | HRH2 (0.67) | KDM4EHRH2HRH1HRH3 | |
| SCHEMBL5215408 | 0.74 | HRH2 (0.69) | KDM4EHRH2HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301480-B1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LAB (US) | 2007-09-12 | — | — | EP | disclosed |