Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 18/20 | 0.41 |
| ▸ | DRD3 | P35462 | 18/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4390760 | 0.87 | DRD2 (0.47) | DRD2DRD3 | |
| SCHEMBL4392580 | 0.85 | DRD2 (0.38) | DRD2DRD3HRH4LRRK2 | |
| SCHEMBL4513972 | 0.85 | DRD2 (0.38) | DRD2DRD3HRH4LRRK2 | |
| SCHEMBL4392586 | 0.85 | DRD2 (0.38) | DRD2DRD3HRH4LRRK2 | |
| SCHEMBL4396041 | 0.76 | DRD2 (0.50) | DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL4520854 | 0.76 | DRD2 (0.49) | DRD2DRD3 | |
| SCHEMBL4392491 | 0.75 | DRD2 (0.49) | DRD2DRD3 | |
| SCHEMBL4392111 | 0.75 | DRD2 (0.47) | DRD2DRD3 | |
| SCHEMBL4399853 | 0.75 | DRD2 (0.50) | DRD2DRD3HRH4 | |
| Hydrochloric Acid SCHEMBL4397256 | 0.74 | DRD2 (0.49) | DRD2DRD3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778684-A1 | 4-PIPERAZINYL-PYRIMIDINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D<sb>3</sb> RECEPTOR | Abbott GmbH & Co. KG (DE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006015842-A1 | 4-PIPERAZINYL-PYRIMIDINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR | ABBOTT GMBH & CO. KG (DE) | 2006-02-16 | — | — | WO | disclosed |