Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 13/20 | 0.58 |
| ▸ | FNTB | P49356 | 13/20 | 0.58 |
| ▸ | PGGT1B | P53609 | 5/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225577 | 0.83 | FNTA (0.58) | FNTAFNTBPGGT1BIDO1 | |
| SCHEMBL7191102 | 0.83 | FNTA (0.47) | FNTAFNTBPGGT1BIDO1 | |
| SCHEMBL7167060 | 0.79 | FNTA (0.47) | FNTAFNTBPGGT1BIDO1 | |
| SCHEMBL7854078 | 0.78 | IDO1 (0.46) | FNTAFNTBPGGT1BIDO1 | |
| SCHEMBL13186537 | 0.73 | FNTA (1.00) | FNTAFNTB | |
| SCHEMBL5514757 | 0.73 | FNTA (0.80) | FNTAFNTBPGGT1BIDO1 | |
| SCHEMBL5733786 | 0.73 | FNTA (1.00) | FNTAFNTB | |
| SCHEMBL6554448 | 0.73 | FNTA (0.41) | FNTAFNTBPGGT1BIDO1 | |
| SCHEMBL168438 | 0.72 | FNTA (0.62) | FNTAFNTBPGGT1BIDO1 | |
| SCHEMBL1198369 | 0.72 | FNTA (0.62) | FNTAFNTBPGGT1BIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1815247-A2 | THERAPEUTIC USE OF FARNESYLTRANSFERASE INHIBITORS AND METHODS OF MONITORING THE EFFICACY THEREOF | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006052718-A2 | FARNESYLTRANSFERASE INHIBITORS FOR TREATING SEPSIS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-18 | — | — | WO | disclosed |
| EP-1365763-A1 | FARNESYL PROTEIN TRANSFERASE INHIBITOR COMBINATIONS WITH ANTIESTROGEN AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002064142-A1 | FARNESYL PROTEIN TRANSFERASE INHIBITOR COMBINATIONS WITH ANTIESTROGEN AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-08-22 | — | — | WO | disclosed |