SCHEMBL7854078

SCHEMBL7854078

Cn1cncc1-c1c(-c2cccc(Cl)c2)c2cc(C(O)c3ccc(Cl)cc3)ccc2n2nnnc12

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.46
FNTA P49354 13/20 0.45
FNTB P49356 13/20 0.45
PGGT1B P53609 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7167060 0.90 FNTA (0.47) IDO1FNTAFNTBPGGT1B
SCHEMBL7855700 0.87 IDO1 (0.47) IDO1FNTAFNTBPGGT1B
SCHEMBL6556871 0.84 IDO1 (0.46) IDO1FNTAFNTBPGGT1B
SCHEMBL6554448 0.83 FNTA (0.41) IDO1FNTAFNTBPGGT1B
SCHEMBL7191102 0.81 FNTA (0.47) IDO1FNTAFNTBPGGT1B
SCHEMBL7855698 0.80 FNTA (0.50) IDO1FNTAFNTBPGGT1B
SCHEMBL7094552 0.79 IDO1 (0.48) IDO1FNTAFNTB
SCHEMBL6987223 0.79 IDO1 (0.48) IDO1FNTAFNTB
SCHEMBL5221738 0.78 FNTA (0.58) IDO1FNTAFNTBPGGT1B
SCHEMBL7644048 0.77 FNTA (0.52) IDO1FNTAFNTBPGGT1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140935-A2 1,2-ANNELATED QUINOLINE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2001-10-10 EP disclosed
WO-2000039082-A2 1,2-ANNELATED QUINOLINE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2000-07-06 WO disclosed