Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 2/20 | 0.69 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.67 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.67 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.67 |
| ▸ | RORC | P51449 | 1/20 | 0.64 |
| ▸ | WDR5 | P61964 | 1/20 | 0.60 |
| ▸ | CTSV | O60911 | 1/20 | 0.57 |
| ▸ | CTSL | P07711 | 1/20 | 0.57 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.55 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.54 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16737210 | 0.82 | CTSV (0.67) | AKR1C4AKR1C3AKR1C2AKR1C1RORC | |
| SCHEMBL6811868 | 0.82 | MAPT (0.64) | GFERAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL1954449 | 0.82 | GFER (0.80) | GFERMAPTMEN1KMT2ARAB9A | |
| SCHEMBL1955845 | 0.81 | GFER (0.78) | GFERMAPTMEN1KMT2AGAA | |
| SCHEMBL1310079 | 0.81 | GFER (0.78) | GFERMAPTMEN1KMT2ARAB9A | |
| SCHEMBL9281809 | 0.80 | GFER (0.76) | GFERMAPTMEN1KMT2AGAA | |
| SCHEMBL1307732 | 0.80 | GFER (0.76) | GFERAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL14413339 | 0.80 | GFER (0.76) | GFERMAPTMEN1KMT2ARAB9A | |
| SCHEMBL1308410 | 0.80 | GFER (0.76) | GFERAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL16737154 | 0.80 | CTSV (0.63) | AKR1C4AKR1C3AKR1C2AKR1C1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1989100-A | Therapeutic compounds | ASTRAZENECA AB (SE) | 2007-06-27 | — | — | CN | disclosed |
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |