Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.65 |
| ▸ | CCNE2 | O96020 | 9/20 | 0.65 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.65 |
| ▸ | CDK2 | P24941 | 9/20 | 0.65 |
| ▸ | ATR | Q13535 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3279262 | 0.99 | GSK3B (0.64) | GSK3BCCNE2CCNE1CDK2ATR | |
| SCHEMBL3279536 | 0.95 | GSK3B (0.67) | GSK3BCCNE2CCNE1CDK2ATR | |
| Hydrochloric Acid SCHEMBL6206046 | 0.92 | GSK3B (0.59) | GSK3BCCNE2CCNE1CDK2ATR | |
| SCHEMBL3274547 | 0.85 | GSK3B (0.78) | GSK3BCCNE2CCNE1CDK2ATR | |
| Hydrochloric Acid SCHEMBL5224249 | 0.85 | GSK3B (0.49) | GSK3BCCNE2CCNE1CDK2ATR | |
| SCHEMBL3273882 | 0.84 | GSK3B (0.67) | GSK3BCCNE2CCNE1CDK2ATR | |
| Hydrochloric Acid SCHEMBL4505372 | 0.84 | CCNE2 (0.53) | GSK3BCCNE2CCNE1CDK2ATR | |
| SCHEMBL3274403 | 0.83 | GSK3B (0.65) | GSK3BCCNE2CCNE1CDK2ATR | |
| SCHEMBL5218515 | 0.81 | GSK3B (0.63) | GSK3BCCNE2CCNE1CDK2ATR | |
| SCHEMBL5219446 | 0.81 | GSK3B (0.51) | GSK3BCCNE2CCNE1CDK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575942-B1 | COMPOUNDS HAVING SELECTIVE INHIBITING EFECT AT GSK3 | ASTRAZENECA AB (SE) | 2007-05-02 | — | — | EP | claimed |