Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.51 |
| ▸ | CDK2 | P24941 | 7/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5224249 | 0.94 | GSK3B (0.49) | GSK3BCCNE2CCNE1CDK2KCNH2 | |
| SCHEMBL5225728 | 0.91 | GSK3B (0.60) | GSK3BCCNE2CCNE1CDK2KCNH2 | |
| SCHEMBL3279536 | 0.86 | GSK3B (0.67) | GSK3BCCNE2CCNE1CDK2KCNH2 | |
| SCHEMBL5221380 | 0.84 | GSK3B (0.51) | GSK3BCCNE2CCNE1CDK2USP2 | |
| Hydrochloric Acid SCHEMBL5223876 | 0.83 | CYP1A2 (0.58) | GSK3BCCNE2CCNE1CDK2SMN1; SMN2 | |
| SCHEMBL5226361 | 0.82 | GSK3B (0.49) | GSK3BCCNE2CCNE1CDK2 | |
| SCHEMBL5221843 | 0.81 | GSK3B (0.65) | GSK3BCCNE2CCNE1CDK2KCNH2 | |
| Hydrochloric Acid SCHEMBL5220027 | 0.81 | GSK3B (0.48) | GSK3BCCNE2CCNE1CDK2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3279262 | 0.80 | GSK3B (0.64) | GSK3BCCNE2CCNE1CDK2KCNH2 | |
| Hydrochloric Acid SCHEMBL5221093 | 0.80 | GSK3B (0.77) | GSK3BCCNE2CCNE1CDK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575942-B1 | COMPOUNDS HAVING SELECTIVE INHIBITING EFECT AT GSK3 | ASTRAZENECA AB (SE) | 2007-05-02 | — | — | EP | claimed |