Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 18/20 | 0.51 |
| ▸ | FAP | Q12884 | 2/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.44 |
| ▸ | PREP | P48147 | 3/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5667975 | 1.00 | DPP4 (0.51) | DPP4FAPDPP7DPP8PREP | |
| SCHEMBL5224577 | 0.88 | DPP4 (0.47) | DPP4FAPDPP7DPP8PREP | |
| SCHEMBL5217855 | 0.83 | DPP4 (0.48) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL5220299 | 0.83 | DPP4 (0.45) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL5221875 | 0.81 | DPP4 (0.48) | DPP4 | |
| SCHEMBL5221665 | 0.80 | HSD11B1 (0.41) | — | |
| SCHEMBL5221882 | 0.77 | DPP4 (0.40) | DPP4FAPDPP7DPP8PREP | |
| SCHEMBL7064555 | 0.76 | DPP4 (0.50) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL7064553 | 0.76 | DPP4 (0.50) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL5206434 | 0.76 | DPP4 (0.63) | DPP4FAPDPP7DPP8PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399433-B1 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-08-22 | — | — | EP | disclosed |
| US-7183290-B2 | Fluoropyrrolidines as dipeptidyl peptidase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-27 | — | — | US | disclosed |