Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.62 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.62 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.52 |
| ▸ | REN | P00797 | 6/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222139 | 1.00 | BACE1 (0.62) | BACE1BACE2KLK5RENAPP | |
| SCHEMBL5222142 | 1.00 | BACE1 (0.62) | BACE1BACE2KLK5RENAPP | |
| SCHEMBL5222134 | 1.00 | BACE1 (0.62) | BACE1BACE2KLK5RENAPP | |
| SCHEMBL5219586 | 0.86 | REN (0.57) | BACE1KLK5RENAPPPSEN1 | |
| SCHEMBL5219578 | 0.86 | REN (0.57) | BACE1KLK5RENAPPPSEN1 | |
| Hydrochloric Acid SCHEMBL5225007 | 0.80 | BACE1 (0.55) | BACE1BACE2REN | |
| Hydrochloric Acid SCHEMBL5224998 | 0.80 | BACE1 (0.55) | BACE1BACE2REN | |
| Hydrochloric Acid SCHEMBL5224992 | 0.80 | BACE1 (0.55) | BACE1BACE2REN | |
| SCHEMBL5387761 | 0.80 | KLK5 (0.59) | KLK5APPPSEN1PSEN2APH1B | |
| SCHEMBL5387766 | 0.80 | KLK5 (0.59) | KLK5APPPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |