Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4863299 | 0.82 | MEN1 (0.47) | MEN1KMT2AUSP2HTTNPSR1 | |
| SCHEMBL5223439 | 0.72 | MEN1 (0.52) | MEN1KMT2AUSP2HTTMAPT | |
| SCHEMBL6768594 | 0.71 | MEN1 (0.54) | MEN1KMT2AUSP2HTTMAPT | |
| SCHEMBL6770955 | 0.69 | MEN1 (0.54) | MEN1KMT2AUSP2HTTMAPT | |
| SCHEMBL4866968 | 0.69 | MEN1 (0.50) | MEN1KMT2AUSP2HTTHTR1A | |
| SCHEMBL4867160 | 0.69 | SLC27A1 (0.51) | MEN1KMT2A | |
| SCHEMBL6769206 | 0.66 | KMT2A (0.52) | MEN1KMT2AHTTMAPTNPSR1 | |
| SCHEMBL4861022 | 0.66 | MEN1 (0.49) | MEN1KMT2ANPSR1KCNH2 | |
| SCHEMBL6769160 | 0.66 | KMT2A (0.51) | MEN1KMT2AHTTMAPTNPSR1 | |
| SCHEMBL6768966 | 0.66 | KMT2A (0.51) | MEN1KMT2AUSP2HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1806346-A1 | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors | CV THERAPEUTICS, INC. (US) | 2007-07-11 | — | — | EP | disclosed |
| EP-1567525-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS AND THEIR USE AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS, INC. (US) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004052887-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS AND THEIR USE AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS, INC. (US) | 2004-06-24 | — | — | WO | disclosed |