Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 20/20 | 1.00 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1461318 | 1.00 | SLC6A9 (1.00) | SLC6A9SLC6A5KCNH2 | |
| SCHEMBL3871601 | 1.00 | SLC6A9 (1.00) | SLC6A9SLC6A5KCNH2 | |
| SCHEMBL18490920 | 0.94 | SLC6A9 (0.89) | SLC6A9SLC6A5KCNH2 | |
| SCHEMBL3872054 | 0.93 | SLC6A9 (1.00) | SLC6A9SLC6A5KCNH2 | |
| SCHEMBL3878358 | 0.91 | SLC6A9 (0.84) | SLC6A9SLC6A5KCNH2 | |
| SCHEMBL18502987 | 0.90 | SLC6A9 (0.82) | SLC6A9SLC6A5 | |
| SCHEMBL9882712 | 0.90 | SLC6A9 (0.84) | SLC6A9SLC6A5KCNH2 | |
| SCHEMBL9882711 | 0.90 | SLC6A9 (0.84) | SLC6A9SLC6A5KCNH2 | |
| SCHEMBL3871584 | 0.90 | SLC6A9 (0.81) | SLC6A9SLC6A5 | |
| SCHEMBL3880029 | 0.89 | SLC6A9 (0.80) | SLC6A9SLC6A5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106163520-B | GLYT1 inhibitors for the treatment of hematological disorders | 豪夫迈·罗氏有限公司 | 2019-12-13 | — | — | CN | claimed |
| CN-106163520-B | GLYT1 inhibitors for the treatment of hematological disorders | 豪夫迈·罗氏有限公司 | 2019-12-13 | — | — | CN | disclosed |
| EP-3137073-B1 | GLYT1 INHIBITORS FOR USE IN THE TREATMENT OF HEMATOLOGICAL DISORDERS | HOFFMANN LA ROCHE (CH) | 2018-06-06 | — | — | EP | disclosed |
| EP-1848694-A1 | HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 | F. Hoffmann-Roche AG (CH) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006082001-A1 | HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 | F.HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | disclosed |