Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | KLK7 | P49862 | 1/20 | 0.52 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 7/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 2/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | REN | P00797 | 1/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 3/20 | 0.49 |
| ▸ | FNTA | P49354 | 1/20 | 0.49 |
| ▸ | FNTB | P49356 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30406651 | 1.00 | CA1 (0.57) | CA1KLK7KLK5CTSKSYK | |
| SCHEMBL29813279 | 0.98 | CA1 (0.55) | CA1KLK7KLK5CTSKSYK | |
| SCHEMBL29813227 | 0.90 | CTSK (0.49) | CA1KLK7KLK5CTSKSYK | |
| SCHEMBL28647259 | 0.90 | BACE1 (0.56) | CA1KLK7KLK5CTSKCTSB | |
| SCHEMBL28647258 | 0.90 | BACE1 (0.56) | CA1KLK7KLK5CTSKCTSB | |
| SCHEMBL29813491 | 0.89 | CTSK (0.52) | CA1KLK7KLK5CTSKSYK | |
| SCHEMBL3169245 | 0.88 | CA1 (0.59) | CA1CTSKCTSLCTSBFNTA | |
| SCHEMBL4487966 | 0.88 | CA1 (0.59) | CA1CTSKCTSLCTSBFNTA | |
| SCHEMBL4474296 | 0.88 | CA1 (0.59) | CA1CTSKCTSLCTSBFNTA | |
| SCHEMBL4467787 | 0.88 | CA1 (0.59) | CA1CTSKCTSLCTSBFNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444201-B1 | 2-(3-SULFONYLAMINO-2-OXOPYRROLIDIN-1-YL)PROPANAMIDES AS FACTOR XA INHIBITORS | GLAXO GROUP LTD (GB) | 2007-09-12 | — | — | EP | disclosed |
| US-7179835-B2 | 2-(3-sulfonylamino-2-oxopyrrolidin-1-yl)propanamides as factor xa inhibitors | GLAXO GROUP LIMITED (GB) | 2007-02-20 | — | — | US | disclosed |