Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 4/20 | 0.55 |
| ▸ | MET | P08581 | 8/20 | 0.52 |
| ▸ | KDR | P35968 | 7/20 | 0.52 |
| ▸ | MST1R | Q04912 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2868796 | 0.87 | MET (0.69) | FGFR2METKDRMST1RAXL | |
| SCHEMBL2859660 | 0.81 | FGFR2 (0.71) | FGFR2METKDRMST1RPDGFRA | |
| SCHEMBL2855809 | 0.80 | FGFR2 (0.55) | FGFR2METKDRMST1RPDGFRA | |
| SCHEMBL2865331 | 0.79 | MET (0.62) | FGFR2METKDRMST1RALDH1A1 | |
| SCHEMBL2869130 | 0.78 | MET (0.59) | FGFR2METKDRMST1RALDH1A1 | |
| SCHEMBL2863464 | 0.77 | MET (0.65) | FGFR2METKDRMST1RALDH1A1 | |
| SCHEMBL2868731 | 0.76 | MET (0.63) | FGFR2METKDRMST1RPDGFRA | |
| SCHEMBL2865369 | 0.75 | MET (0.62) | FGFR2METKDRMST1RPDGFRA | |
| SCHEMBL2854025 | 0.75 | MET (0.70) | FGFR2METKDRMST1RPDGFRA | |
| SCHEMBL3913859 | 0.75 | MET (0.64) | FGFR2METKDRMST1RPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1827434-B1 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | AMGEN INC (US) | 2014-01-15 | — | — | EP | disclosed |
| US-7652009-B2 | Substituted heterocycles and methods of use | AMGEM INC. (US) | 2010-01-26 | — | — | US | disclosed |
| US-7652009-B2 | Substituted heterocycles and methods of use | AMGEM INC. (US) | 2010-01-26 | — | — | US | disclosed |
| EP-1827434-A2 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | Amgen Inc. (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006060318-A2 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | AMGEN INC. (US) | 2006-06-08 | — | — | WO | disclosed |