SCHEMBL5223462

SCHEMBL5223462

CC(C)(C)[Si](C)(C)OC(CO)c1ccc(F)cc1

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 2/20 0.37
TRPA1 O75762 1/20 0.34
SLC6A4 P31645 3/20 0.33
SLC6A2 P23975 2/20 0.33
CA2 P00918 1/20 0.32
ADRB2 P07550 1/20 0.32
ADRB1 P08588 1/20 0.32
ADRB3 P13945 1/20 0.32
IDO1 P14902 2/20 0.32
TDO2 P48775 2/20 0.32
SLC6A3 Q01959 1/20 0.31
APLNR P35414 2/20 0.31
TRPV3 Q8NET8 1/20 0.31
KCNH3 Q9ULD8 2/20 0.31
LMNA P02545 1/20 0.31
NOX1 Q9Y5S8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31201875 0.85 CA2 (0.33) SLC6A4SLC6A2CA2LMNA
SCHEMBL5218896 0.84 SLC6A4 (0.36) SLC6A4SLC6A2IDO1SLC6A3APLNR
SCHEMBL3499175 0.84 AOC3 (0.37) AOC3SLC6A4SLC6A2CA2IDO1
SCHEMBL16843269 0.84 AOC3 (0.37) AOC3SLC6A4SLC6A2CA2IDO1
SCHEMBL1739510 0.83 GSR (0.44) AOC3TRPA1SLC6A4SLC6A2CA2
SCHEMBL8405099 0.83 GSR (0.44) AOC3TRPA1SLC6A4SLC6A2CA2
SCHEMBL14984000 0.83 GSR (0.44) AOC3TRPA1SLC6A4SLC6A2CA2
SCHEMBL15948268 0.81 AOC3 (0.39) AOC3SLC6A4SLC6A2CA2IDO1
SCHEMBL27933551 0.81 CA2 (0.36) AOC3SLC6A4SLC6A2CA2IDO1
SCHEMBL15229070 0.81 SLC6A2 (0.38) SLC6A4SLC6A2SLC6A3APLNRTRPV3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709725-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF Progentos Therapeutics, Inc. (US) 2026-03-18 EP disclosed
WO-2024233642-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF PROGENTOS THERAPEUTICS, INC. (US) 2024-11-14 WO disclosed
EP-1765810-A1 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY Decode Chemistry, Inc. (US) 2007-03-28 EP disclosed
WO-2005123724-A1 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY DECODE CHEMISTRY, INC. (US) 2005-12-29 WO disclosed