⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224346 | 1.00 | — | — | |
| SCHEMBL5224339 | 1.00 | — | — | |
| SCHEMBL5217332 | 0.80 | KDM4E (0.38) | — | |
| SCHEMBL5217321 | 0.80 | KDM4E (0.38) | — | |
| SCHEMBL5217318 | 0.80 | KDM4E (0.38) | — | |
| SCHEMBL5217221 | 0.72 | — | — | |
| SCHEMBL5217230 | 0.72 | — | — | |
| SCHEMBL5217238 | 0.72 | — | — | |
| SCHEMBL5217329 | 0.68 | YTHDC1 (0.34) | — | |
| SCHEMBL5219296 | 0.68 | KDM4E (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253198-B2 | Hydroxyethylamine derivatives for the treatment of Alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2007-08-07 | — | — | US | disclosed |
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2006-02-02 | — | — | US | disclosed |