Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluoride SCHEMBL10600498 | 0.98 | POLB (0.37) | POLBKDM4ENPC1CYP1A2CYP2D6 | |
| SCHEMBL11099897 | 0.75 | MEN1 (0.31) | MEN1KMT2ACHRM2CHRM4CHRM5 | |
| SCHEMBL5309238 | 0.74 | DDB1 (0.42) | POLBKDM4ENPC1CYP1A2CYP2D6 | |
| SCHEMBL27427689 | 0.72 | DDB1 (0.35) | DDB1CRBNALDH1A1NFKB1NFKB2 | |
| SCHEMBL9116182 | 0.71 | DDB1 (0.37) | POLBDDB1CRBNALDH1A1NFKB1 | |
| SCHEMBL27917014 | 0.71 | DDB1 (0.34) | KDM4EMAPK1DDB1CRBNALDH1A1 | |
| SCHEMBL5695189 | 0.71 | DDB1 (0.34) | KDM4EMAPK1DDB1CRBNALDH1A1 | |
| SCHEMBL7634555 | 0.71 | ALDH1A1 (0.51) | POLBALDH1A1LMNAGFER | |
| SCHEMBL28725156 | 0.70 | DDB1 (0.33) | DDB1CRBNALDH1A1MEN1LMNA | |
| SCHEMBL25360423 | 0.69 | TACR1 (0.46) | CYP1A2CYP2D6CYP2C19MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812425-A2 | C-FMS KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006047479-A2 | C-FMS KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-04 | — | — | WO | disclosed |