Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 13/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | MAX | P61244 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653773 | 0.90 | GCK (0.43) | GCKKCNH2MYCMAX | |
| SCHEMBL2654282 | 0.81 | SMN1; SMN2 (0.51) | GCKHPGDALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL2655556 | 0.75 | GCK (0.52) | GCKKCNH2 | |
| SCHEMBL2653455 | 0.75 | AR (0.41) | GCKALDH1A1KCNH2TSHRHTT | |
| SCHEMBL22510110 | 0.74 | HPGD (0.63) | HPGDALDH1A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL2653534 | 0.74 | GCK (0.58) | GCKKCNH2 | |
| SCHEMBL22510117 | 0.73 | ALDH1A1 (0.46) | HPGDALDH1A1KDM4ECYP3A4CYP2C9 | |
| SCHEMBL2653597 | 0.72 | MYC (0.41) | GCKKCNH2MYCMAX | |
| SCHEMBL2664533 | 0.71 | ALDH1A1 (0.67) | HPGDALDH1A1KDM4EKCNH2TSHR | |
| SCHEMBL1797368 | 0.70 | GCK (0.40) | GCKHPGDALDH1A1KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578745-B1 | BENZOFURAN DERIVATivES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREOF | ASTRAZENECA AB (SE) | 2007-11-14 | — | — | EP | disclosed |