Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.65 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | JAK1 | P23458 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
| ▸ | HPGDS | O60760 | 4/20 | 0.50 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13360583 | 0.85 | HRH3 (0.64) | HRH3JAK2JAK1JAK3USP30 | |
| SCHEMBL2145523 | 0.85 | HRH3 (0.48) | HRH3USP30HPGDS | |
| SCHEMBL1978278 | 0.82 | HRH3 (0.56) | HRH3JAK2JAK1JAK3USP30 | |
| SCHEMBL21551734 | 0.82 | DEGS1 (0.49) | HRH3USP30HPGDSSMO | |
| SCHEMBL6139686 | 0.82 | HRH3 (0.60) | HRH3JAK2JAK1JAK3USP30 | |
| SCHEMBL6140027 | 0.82 | HRH3 (0.58) | HRH3JAK2JAK1JAK3KDM1A | |
| SCHEMBL14843687 | 0.82 | HRH3 (0.58) | HRH3JAK2JAK1JAK3KDM1A | |
| SCHEMBL30754007 | 0.82 | HRH3 (0.58) | HRH3JAK2JAK1JAK3KDM1A | |
| SCHEMBL2006084 | 0.81 | DEGS1 (0.51) | HRH3SMO | |
| SCHEMBL1999758 | 0.81 | HRH3 (0.51) | HRH3USP30HPGDSSMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664025-B1 | PYRROL DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | ASTRAZENECA AB (SE) | 2007-09-19 | — | — | EP | disclosed |