Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | JAK1 | P23458 | 1/20 | 0.57 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.47 |
| ▸ | NNMT | P40261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223723 | 0.85 | HRH3 (0.65) | HRH3JAK2JAK1JAK3USP30 | |
| SCHEMBL30754007 | 0.83 | HRH3 (0.58) | HRH3JAK2JAK1JAK3KDM1A | |
| SCHEMBL14843687 | 0.83 | HRH3 (0.58) | HRH3JAK2JAK1JAK3KDM1A | |
| SCHEMBL6140027 | 0.83 | HRH3 (0.58) | HRH3JAK2JAK1JAK3KDM1A | |
| Hydrochloric Acid SCHEMBL5009902 | 0.82 | HRH3 (0.57) | HRH3JAK2JAK1JAK3KDM1A | |
| Hydrochloric Acid SCHEMBL5221468 | 0.82 | HRH3 (0.57) | HRH3JAK2JAK1JAK3KDM1A | |
| SCHEMBL30754057 | 0.81 | HRH3 (0.64) | HRH3JAK2JAK1JAK3KDM1A | |
| SCHEMBL6139686 | 0.81 | HRH3 (0.60) | HRH3JAK2JAK1JAK3USP30 | |
| SCHEMBL1978278 | 0.81 | HRH3 (0.56) | HRH3JAK2JAK1JAK3USP30 | |
| Hydrochloric Acid SCHEMBL27796614 | 0.81 | HRH3 (0.43) | HRH3JAK2JAK1JAK3KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324385-B2 | Diacylglycerol acyltransferase inhibitors | MADRIGAL PHARMACEUTICALS, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100113782-A1 | Diacylglycerol Acyltransferase Inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113782-A1 | Diacylglycerol Acyltransferase Inhibitors | DGAT2, DGAT1, MOGAT2 | HRH3 1670/4885JAK2 1804/4885JAK1 4080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.