Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 7/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3453567 | 0.89 | HSD11B1 (0.47) | AXLHSD11B1KDRKDM4EKMT2A | |
| SCHEMBL3452912 | 0.83 | AXL (0.45) | AXLKDRKDM4EKMT2AMEN1 | |
| SCHEMBL3452933 | 0.83 | CHKA (0.44) | AXLKDRKDM4ECDK4 | |
| SCHEMBL3453508 | 0.75 | HSD11B1 (0.46) | AXLHSD11B1KDM4EKMT2APKM | |
| SCHEMBL3453473 | 0.73 | KMT2A (0.45) | AXLKDRKDM4EKMT2AMEN1 | |
| SCHEMBL12725510 | 0.73 | KMT2A (0.56) | AXLKDRKDM4EKMT2AMEN1 | |
| SCHEMBL15759153 | 0.73 | KMT2A (0.56) | AXLKDRKDM4EKMT2AMEN1 | |
| SCHEMBL17166950 | 0.73 | KDM4E (0.57) | AXLKDRKDM4EKMT2AMEN1 | |
| SCHEMBL13698447 | 0.73 | KDM4E (0.57) | AXLKDRKDM4EKMT2AMEN1 | |
| SCHEMBL11315406 | 0.73 | KDM4E (0.57) | AXLKDRKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753429-A1 | MODULATORS OF MUSCARINIC RECEPTORS | Vertex Pharmaceuticals Incorporated (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005117883-A1 | MODULATORS OF MUSCARINIC RECEPTORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-12-15 | — | — | WO | disclosed |