Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.70 |
| ▸ | CTSD | P07339 | 3/20 | 0.70 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13496326 | 0.92 | BACE1 (0.82) | BACE1CTSDBACE2 | |
| SCHEMBL4906608 | 0.92 | BACE1 (0.82) | BACE1CTSDBACE2 | |
| SCHEMBL14184576 | 0.88 | BACE1 (0.71) | BACE1CTSDBACE2 | |
| SCHEMBL13496324 | 0.88 | BACE1 (0.71) | BACE1CTSDBACE2 | |
| SCHEMBL4901919 | 0.87 | BACE1 (0.69) | BACE1CTSDBACE2 | |
| SCHEMBL13496329 | 0.85 | BACE1 (0.84) | BACE1CTSDBACE2 | |
| SCHEMBL14184574 | 0.85 | BACE1 (0.84) | BACE1CTSDBACE2 | |
| SCHEMBL5225346 | 0.85 | BACE1 (0.63) | BACE1CTSDBACE2 | |
| SCHEMBL14271257 | 0.85 | BACE1 (0.72) | BACE1CTSDBACE2 | |
| SCHEMBL13496337 | 0.85 | BACE1 (0.63) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799660-A2 | AMINO-CONTAINING COMPOUNDS WHICH INHIBIT MEMAPSIN 2 BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006034296-A2 | AMINO-CONTAINING COMPOUNDS WHICH INHIBIT MEMAPSIN 2 BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2006-03-30 | — | — | WO | disclosed |