Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.63 |
| ▸ | CTSD | P07339 | 3/20 | 0.63 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4910917 | 0.92 | BACE1 (0.72) | BACE1CTSDBACE2 | |
| SCHEMBL5224233 | 0.85 | BACE1 (0.70) | BACE1CTSDBACE2 | |
| SCHEMBL3373001 | 0.84 | BACE1 (0.63) | BACE1CTSDBACE2 | |
| SCHEMBL4908987 | 0.83 | BACE1 (0.75) | BACE1CTSDBACE2 | |
| SCHEMBL4909362 | 0.82 | BACE1 (0.74) | BACE1CTSDBACE2 | |
| SCHEMBL3375521 | 0.82 | BACE1 (0.81) | BACE1CTSDBACE2 | |
| SCHEMBL3375528 | 0.82 | BACE1 (0.81) | BACE1CTSDBACE2 | |
| SCHEMBL4908564 | 0.82 | BACE1 (0.76) | BACE1CTSDBACE2 | |
| SCHEMBL14271275 | 0.82 | BACE1 (0.73) | BACE1CTSDBACE2 | |
| SCHEMBL14271302 | 0.81 | BACE1 (0.75) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799660-A2 | AMINO-CONTAINING COMPOUNDS WHICH INHIBIT MEMAPSIN 2 BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006034296-A2 | AMINO-CONTAINING COMPOUNDS WHICH INHIBIT MEMAPSIN 2 BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2006-03-30 | — | — | WO | disclosed |